Title 
       Increased expression of nucleoside diphosphate
       kinases/nm23 in human diploid fibroblasts transformed by
       SV40 large T antigen or 60Co irradiation. 
Author 
       Ohneda K; Fukuda M; Shimada N; Ishikawa N; Ichou T; Kaji K;
       Toyota T; Kimura N 
Address 
       Department of Molecular Biology, Tokyo Metropolitan
       Institute of Gerontology, Japan. 
Source 
       FEBS Lett, 1994 Jul 18, 348:3, 273-7 
Abstract 
       When the expression levels of nucleoside diphosphate
       (NDP) kinase/nm23 were examined in four human normal
       diploid fibroblast cell lines in comparison with their
       corresponding immortalized cells transformed by SV40
       large T antigen or 60Co irradiation, mRNA levels of the
       two isoforms (NDP kinase A/nm23-H1, NDP kinase
       B/nm23-H2) were increased in the immortalized cell lines.
       The increase was found to be associated with increased
       translation products. Furthermore, the cell extracts
       prepared from these immortalized cell lines demonstrated
       slightly higher enzyme activity than those from their
       normal counterparts. Neither the growth state nor the in
       vitro aging largely affected their expression in a normal
       cell line (TIG-3) examined. The results suggest possible
       involvement of NDP kinases/nm23 in acquiring an infinite
       growth property of these cells.